Proton Pump Inhibitors (PPIs) are a class of drugs widely recognized for their effectiveness in reducing stomach acid production. They work by irreversibly inhibiting the H+/K+ ATPase enzyme system, commonly referred to as the proton pump, which is located on the parietal cells of the stomach lining. This mechanism allows PPIs to effectively treat conditions such as gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and peptic ulcers, providing relief from symptoms like heartburn, acid regurgitation, and abdominal discomfort.

Beyond their primary use in acid-related disorders, PPIs are also integral in preventing gastrointestinal complications in patients on long-term nonsteroidal anti-inflammatory drugs (NSAIDs), which are known to cause gastric irritation and ulcers. Recent studies indicate potential additional benefits of PPIs, including their use in managing Helicobacter pylori infections when combined with antibiotics. However, long-term PPI use must be monitored due to potential side effects such as nutrient deficiencies, increased susceptibility to certain infections,…